FOXL2 represses the testis-specific enhancer of Sox9 to maintain ovary differentiation
During normal testis development, SRY and SF1 up-regulate Sox9 expression via its testis-specific enhancer element (TESCO), which is crucial for the establishment of the male supporting cell lineage, the Sertoli cells. In contrast, during normal ovarian development, Sox9 expression needs to be down-...
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University College London (University of London)
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564901 |