Novel intracellular mechanisms of NMDA receptor-dependent spinal nociceptive plasticity
Prolonged activation of spinal NMDA receptors, after peripheral inflammation or nerve damage, can activate intracellular signalling cascades leading to plastic changes in synaptic transmission. This results in central sensitization of dorsal horn sensory neurones and manifests in patients as increas...
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University College London (University of London)
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565079 |