Dissecting the telomere-independent pathways underlying human cellular senescence

Cellular senescence is an irreversible program of cell cycle arrest triggered in normal somatic cells in response to a variety of intrinsic and extrinsic stimuli including telomere attrition, DNA damage, physiological stress and oncogene activation. Finding that inactivation of the pRB and p53 pathw...

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Bibliographic Details
Main Author: Rovillain, Emilie Marie Isabelle
Published: University College London (University of London) 2011
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565254