Spi6 in dendritic cell priming of CD8 T cell responses to virus
Spi6 is a serine protease inhibitor. Its main function is inhibition of granzyme B (GrB): it is therefore an anti-apoptotic protein in cytotoxic T cells (CTL), where leakage of GrB from cytotoxic granules into the cytosol can trigger apoptosis. CTLs use GrB release to kill infected cells but they ca...
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Imperial College London
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566367 |