Immunomodulatory roles of par-2 in innate and adaptive immune responses
PAR-2 is a GPCR activated in response to proteolytic cleavage of the N terminus. Previous studies have revealed a critical role for PAR-2 in a murine arthritic model, reporting PAR-2 KO mice are resistant to disease. Further studies have identified PAR-2 on rheumatoid synovial CD68+ macrophages. Als...
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University of the West of Scotland
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569069 |