Towards the total synthesis of RP-66453
This thesis outlines synthetic work towards the total synthesis of RP-66453, a natural product isolated from a strain of Actinomycetes bacteria which has been shown to bind to the neurotensin antagonist of guinea pigs. The synthesis of several analogues of the biaryl ether macrocycle of RP-66453 hav...
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University of Southampton
2012
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572744 |