Directed evolution of angiopoietin-binding proteins by somatic hypermutation and cell surface display
Angiopoietin-2 (Ang2) is a secreted ligand that promotes blood vessel destabilisation, remodelling, leakage and inflammation in response to pro-inflammatory activators. In binding to its primary receptor, Tie2, it functions as a competitive antagonist of the anti-inflammatory and pro-quiescent agoni...
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University of Leicester
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574130 |