The proto-oncoprotein PRAME associates with the Cullin-2E3 ubiquitin ligase complex and is upregulated in response to bacterial pathogen associated molecual patterns
PRAME (preferentially expressed antigen in melanoma) is a cancer-testis antigen that is expressed in normal testis tissue and is detected at high levels in a number of haematological and solid organ malignancies. Little is known about the physiological function of PRAME, although a role in the repre...
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University of Nottingham
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574661 |