Dual transgenesis of T cells with a CD44v6-specific chimeric antigen receptor and a suicide gene for the safe eradication of chemoresistant leukaemia and myeloma
The recent and extraordinaire clinical successes of T cells modified with chimeric antigen receptors (CAR) against B-cell tumours indicate this strategy as the new frontier for the immunotherapy of haematological malignancies. In this study, we investigated a new CAR-based strategy for the treatment...
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Open University
2012
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578662 |