Crystallographic, computational and biochemical studies of inhibitors of dihydroorotate dehydrogenases
Pyrimidine biosynthesis represents an attractive target for chemotherapeutic intervention in the treatment of a number of diseases. The enzyme dihydroorotate dehydrogenase (DHODH), which catalyses the fourth reaction in the de novo pyrimidine .biosvnthesis pathway, has for many years received partic...
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University of Leeds
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578681 |