Single cell analysis of Keap1-Nrf2 dynamics
The transcription factor Nrf2 is a master regulator of cytoprotective gene expression. Nrf2 is negatively controlled by Keap1, a sensor protein which allows Nrf2 to respond to changing cellular conditions. In the basal state, Nrf2 binds to two sites of a Keap1 dimer allowing its ubiquitination in a...
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University of Dundee
2013
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578911 |