New genes involved in the synthesis of diphthamide, a modification of eukaryotic translation elongation factor 2 with roles in diphtheria disease and ovarian cancer formation
Diphthamide, the target of Diphtheria toxin, is a unique post-translational modification on His₆₉₉ (S. cerevisiae) of translation elongation factor 2 (eEF2) found in eukarya and archaea. It serves as the unique target for bacterial ADP-ribosylating toxins such as Diphtheria Toxin, Exotoxin A and Cho...
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University of Leicester
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579197 |