The response to chemical stress : development of preclinical and translational biomarkers of Nrf2 activity
Nrf2 is a transcription factor that plays a vital role in the cytoprotective response to oxidative stress. Under basal conditions Nrf2 is sequestered in the cytosol by Keap1, a molecule which targets Nrf2 for ubiquitination and subsequent proteasomal degradation. Following oxidative insult, Keap1 is...
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University of Liverpool
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579345 |