Role of oncogene-induced senescence in thyroid carcinogenesis
Oncogene-induced senescence (OIS) is an irreversible G 1 cell cycle arrest triggered by aberrant expression of oncogenes. The arrest observed during senescence is implemented mainly through activation of p53 and the upregulation of the cyclin-dependent kinase (CDK) inhibitors, p16INK4a and p21cIPl....
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Open University
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580647 |