Synthesis and evaluation of inhibitors against vitamin D3 and all-trans retinoic acid metabolising enzymes as potential therapy for androgen-independent prostate cancer
1alpha25-Dihydroxyvitamin D3 (1alpha,25-(OH)2-D 3) and all-trans retinoic acid (ATRAA) have differentiating and anti-proliferative effects on prostate cancer cells. However, the use of 1alpha,25-(OH)2-D3 and ATRA is limited by the induction of the cytochrome P450 enzymes. A drug which can prolong th...
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Cardiff University
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583588 |