Design and synthesis of potential inhibitors against dUTPase, a novel drug target for the control of protozoal and bacterial infections
The enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that can be considered as the first line of defence against misincorporation of uracil into DNA. Inhibition of dUTPase is lethal in E. coli, S. cervvisiae 'y) and is also likely to be lethal in many other...
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Cardiff University
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583641 |