The role of metal ions and reactive oxygen species in Beta - amyloid aggregation and toxicity and their relevance to Alzheimer's disease
The aggregation and deposition of ß-amyloid (Aß) in the brain has long been implicated in the neurotoxic pathways causing Alzheimer's disease (AD). Recent data suggests that early, soluble oligomers of Aß are the toxic species. Oxidative stress may be partly responsible for the toxicity of the...
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Lancaster University
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.587488 |