The role of multivesicular bodies in the trafficking of the amyloid precursor protein
In Alzheimer’s disease, the beta-amyloid (Aβ) protein accumulates within neurons prior to amyloid plaque development. Recent evidence suggests that intracellular Aβ accumulation, rather than extracellular plaques, correlates best with disease progression. Aβ is generated by proteolytic processing of...
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University College London (University of London)
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.587688 |