A whole genome RNAi screen to identify novel promoters of PINK1/Parkin-mediated mitophagy
The PINK1/Parkin pathway is genetically linked to recessive forms of Parkinson's disease (PD) and plays a central role in the maintenance of mitochondrial homeostasis. Following toxification with the membrane uncoupler CCCP, PINK1, a serine/threonine kinase, becomes stabilised on the outer memb...
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University of Sheffield
2013
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589263 |