The recognition of HLA-B27 by CD4+ T lymphocytes

Studies in B27 transgenic animal models of the spondyloarthropathies (SpA) have demonstrated a requirement for HLA-B27, CD4+ T cells, and bacteria to induce arthritis. This has led to the hypothesis that CD4+ T cells, which usually interact with MHC class II molecules, might recognise HLA-B27. The a...

Full description

Bibliographic Details
Main Author: Boyle, L. H.
Published: University of Cambridge 2002
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596838