Statistical methods for linkage disequilibrium mapping of disease susceptibility genes in candidate regions

Within tightly linked regions of the genome it is often inefficient to genotype and test all polymorphisms for an association with disease since the high degree of linkage disequilibrium causes high levels of redundancy. It has long been suggested that an informative subset of these polymorphisms sh...

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Bibliographic Details
Main Author: Chapman, J. M.
Published: University of Cambridge 2005
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597484