Synthesis of discodermolide and related microtubule stabilising agents
Discodermolide (1) and dictyostatin (211) are polyketide metabolites, isolated from marine sponges, which display potent activity as antimitotic agents with a similar mechanism of action to Taxol<sup>®</sup> (paclitaxel), by stabilising microtubules and promoting the polymerisation of tu...
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University of Cambridge
2006
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599491 |