Structural characterisation of the N-terminal α-helical region of BubR1 essential for the mitotic checkpoint
If the kinetochore is incorrectly or not attached to the spindle, the mitotic checkpoint arrests the cell cycle by inhibiting the ubiquitin ligase activity of the anaphase promoting complex/cyclosome. BubR1 (Budding uninhibited by benomyl), a multi-domain kinase essential for the mitotic checkpoint,...
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University of Cambridge
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599534 |