Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
Sialic acid binding Ig-like lectin-7 (Siglec-7), expressed primarily on NK cells, binds preferentially to alpha2,8 linked disialic acids such as present in the ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as an inhibitory receptor as it contains immunoreceptor tyros...
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University of Dundee
2013
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600747 |