The role of a dynamic conformational ensemble in molecular recognition, activation and drug design

The bioaminergic receptors belong to the G protein-coupled receptors and represent the important drug targets for cardiovascular and neurodegenerative disorders. In this work, molecular dynamics simulations of the bioaminergic receptors in the free form and ligand bound forms have been conducted in...

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Bibliographic Details
Main Author: Selvam, Balaji
Published: Queen's University Belfast 2013
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603067