Integration-deficient lentiviral vectors delivering neurotrophic factors for gene therapy of Parkinson's disease
Parkinson's disease (PD) results from the loss of nigra I dopaminergic neurons and subsequent depletion of striatal dopamine. Direct injection of neurotrophic factors has shown encouraging protection in animal models of PD. However, clinical delivery of protein requires administration by implan...
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Royal Holloway, University of London
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604022 |