The mechanism and consequences of recombination hotspot recognition by an AddAB-type helicase-nuclease

Over billions of years cells have evolved numerous conserved repair pathways to deal with the continuous onslaught of DNA damage. One particularly toxic lesion is a double-stranded DNA break, which can be faithfully repaired by the ubiquitous homologous recombination pathway. In bacteria, the proces...

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Bibliographic Details
Main Author: Gilhooly, Neville S.
Published: University of Bristol 2013
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618823