Analysis of the requirement for the Chx10 homeobox gene and FGF signalling for normal retinal development
Mutation in the human CHX10 homeobox gene causes microphthalmia, and the ocular retardation (Chx10^{orJ/orJ}) mouse models this phenotype. Lack of Chx10 causes reduced proliferation of retinal progenitor cells, resulting in an abnormally small neural retina, as well as loss of the optic nerve and fa...
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University College London (University of London)
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625168 |