The molecular basis of E2A-HLF induced precursor-B cell acute lymphoblastic leukaemia in childhood
Translocation t(17;19)(q21-22;p13) occurs in a small subset (0.5-1%) of childhood precursor B (Pre-B) cell acute lymphoblastic leukaemia (ALL), and produces a chimeric transcription factor, E2A-HLF, which is a fusion oncoprotein. E2A-HLF expression confers a poor clinical outcome with a high risk of...
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University College London (University of London)
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625187 |