Role of the localization of Vav1 during T cell activation
Vav1 is a haematopoietic-specific guanine nucleotide exchange factor for Rho-family GTPases that acts downstream of antigen receptors and regulates events such as lymphocyte proliferation, cytoskeletal reorganization, calcium flux and the activation and clustering of integrins. It is well establishe...
| Main Author: | |
|---|---|
| Published: |
University College London (University of London)
2010
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625292 |