Manipulation of the VHL/HIF pathway in mouse kidney epithelia and pancreatic β-cells
Biallelic inactivation of the von Hippel-Lindau tumour suppressor gene (VHL) underlies both, sporadic clear cell renal cell carcinoma (ccRCC) that arises as part of an inherited multi-cancer VHL syndrome. Pancreatic tumours also occur in VHL disease and are thought to be of neuroendocrine origin. Th...
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University College London (University of London)
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625583 |