Characterisation of the bioreactor environment and its effect on mammalian cell performance in suspension culture during antibody production
The production of therapeutic proteins with complex post-translational modifications is typically performed with suspension adapted mammalian cells, in stirred tank bioreactors (STRs). In this environment cells are exposed to hydrodynamic forces derived from both agitation and aeration. An improved...
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University College London (University of London)
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626396 |