The role of the ubiquitin-proteasome system in prion disease pathogenesis
Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrPSc) in the brain. They are caused by the conformational rearrangement of the normal cellular protein, PrPC, to the abnormal isoform PrPSc. The critical relationship betwee...
| Main Author: | |
|---|---|
| Published: |
University College London (University of London)
2013
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626399 |