The design, synthesis and evaluation of novel cyclohexadienones as cancer chemopreventive agents
Reactive oxygen species (ROS) have been identified as one cause of genetic mutations associated with carcinogenesis. The cellular response to ROS is to upregulate the production of an array of detoxifying enzymes. Experimental evidence shows that the Keap1/Nrf2 complex plays a crucial role in this a...
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University College London (University of London)
2014
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626745 |