Statistical modelling of mitochondrial disease

Mitochondrial DNA mutations are a major cause of disease in the human population. Understanding the disease associated with these mutations is complicated by heteroplasmy, the mixture of wild-type and mutated mitochondrial DNA. Heteroplasmy can vary between cells, tissues, and organs, and the diseas...

Full description

Bibliographic Details
Main Author: Grady, John Patrick
Published: University of Newcastle upon Tyne 2014
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627702