Elucidating the molecular mechanism of TRIB2-mediated degradation of C/EBPa in AML
The pseudokinase TRIB2 is a potent AML oncogene, capable of inducing transplantable AML with a relatively short latency in murine models. Functionally, the oncogenicity of TRIB2 has been linked to its degradation of C/EBPα, a transcription factor necessary for regulation of HSCs, myeloid differentia...
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University of Glasgow
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.630996 |