Predicting structural and energetic effects of mutations at protein-protein interfaces

Understanding the structural, dynamical and energetic basis of protein-protein interactions (PPIs) is key for a number of research disciplines. Predicting which sites in PPIs show potential for modulation with binding free energy (ΔG) calculations allows experimental work to be targeted and inhibito...

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Bibliographic Details
Main Author: Bradshaw, Richard Thomas
Other Authors: Leatherbarrow, Robin ; Gould, Ian ; Tate, Ed
Published: Imperial College London 2013
Subjects:
540
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.631188