To establish the role of mutations in c-KIT tyrosine kinase in the pathogenesis and therapy of core-binding factor-related acute myeloid leukaemia (AML)
Haematopoiesis is controlled by complex signal transduction pathways and transcription regulators which may become dysregulated in acute myeloid leukaemia (AML). Activating mutations in FLT3 and c-KIT receptor tyrosine kinases (RTKs) are commonly found in AML and can impact on prognosis. Different t...
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University College London (University of London)
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.631890 |