The role of protein kinase D signalling in the induction of collagenase gene expression in human articular chondrocytes
The destruction of articular cartilage is a central feature of arthritis. The activity of collagenase enzymes, induced by pro-inflammatory cytokines, is a key step in this process. Collagenases have been targeted therapeutically but trials have not proven beneficial due to off-target effects. Unders...
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University of Newcastle upon Tyne
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639773 |