Ligand design for two proteins of therapeutic relevance
Elastase is irreversibly inhibited by compounds incorporating a β-lactam ring and this thesis describes structural studies on three classes of β-lactam inhibitor. The mechanism of inhibition begins with nucleophilic attack by the catalytic serine on the carbonyl which is at position 2 of all the β-l...
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University of Edinburgh
2001
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.640488 |