Design and synthesis of novel inhibitors of the p53-Mdm2 interaction and the development of novel inhibitors of cyclin dependent kinases

The disruption of the p53-Mdm2 interaction is an attractive therapeutic strategy for activating p53 tumour suppressor activity in tumours expressing wild type p53. One such strategy for the disruption of the P53-Mdm2 interaction is the design of low molecular weight ligands that bind at the p53-Mdm2...

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Bibliographic Details
Main Author: Bailey, Kevin Roy
Published: University of Edinburgh 2004
Subjects:
615
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.641199