Mitochondrial DNA replication and biogenesis during embryonic development and in disease
Regulation of mtDNA content is critical to normal human health and is often abnormal in mitochondrial diseases. Only a proportion of a female’s mtDNA is used to populate the oocytes she forms during embryogenesis. This mtDNA bottleneck can cause rapid shifts in heteroplasmy levels between generation...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2014
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.647482 |