Characterisation of the ATP binding motif of PRP2
Four dominant negative mutants of PRP2 were produced by site-directed mutagenesis of the conserved ATP-binding motif (Motif A) of PRP2. These mutants, when overproduced in a wild-type yeast strain caused a growth inhibition due to inhibition of splicing, leading to an accumulation of pre-mRNA. <I...
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University of Edinburgh
1994
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650975 |