Behavioral and histochemical characterization of a novel BACE Knockout x PDAPP mouse model of Alzheimer's Disease : examination of potential effects of BACE inhibition on Alzheimer's Disease and the role of APP, Aβ and BACE in normal and pathological memory function
This dissertation describes the phenotypic characterisation of a BACE knockout (KO) x PDAPP transgenic mouse line, utilising behavioural, histochemical, and pharmagologic methods. Several transgenic mouse models have been created that overexpress human mutant Amyloid Precursor Protein (hAPP) that re...
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University of Edinburgh
2006
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653514 |