Investigations into the mechanism of action of antitumour quinols
Antitumour quinols containing the 4-hydroxycyclohexa-2,5-dienone pharmacophore potently inhibit human tumour cell growth in vitro and in vivo. This activity is postulated to occur via inhibition of the thioredoxin/thioredoxin reductase (TrxlTrxR) redox system which reduces numerous substrates involv...
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University of Nottingham
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659198 |