Towards conditional gene inactivation in the mouse colon and functional analysis of genes influencing colorectal carcinogenesis
Dysregulation of the Wnt signalling pathway is implicated in the carcinogenic transformation of normal cells in a number of human tissues. Mutations in Wnt pathway signalling molecules appear to be particularly important in the development of colorectal neoplasia. This thesis investigates the effect...
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University of Edinburgh
2001
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.660977 |