Tissue sensitivity to glucocorticoids in hypertension
11β-Hydroxysteroid dehydrogenase catalyses the conversion of cortisol to inactive cortisone. In kidney, the enzyme confers aldosterone-specificity on mineralocorticoid receptors by preventing their occupancy by cortisol. The expression of 11β-dehydrogenase in many extra-renal sites suggests that it...
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University of Edinburgh
1993
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663355 |