Alignment and analysis of noncoding DNA sequences in Drosophila

In this project, a fast accurate global pairwise alignment of noncoding DNA sequences, MCALIGN2, is developed based on explicit models of indel evolution. A pair-hidden-Markov-Model (pair-HMM) of seven states and a golden-Section-Search algorithm are employed in this method to search for the most pr...

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Bibliographic Details
Main Author: Wang, Jun
Published: University of Edinburgh 2010
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663450