Design, conduct and analysis of multi-arm multi-stage clinical trials
In this thesis, contributions are made towards improving the design, conduct and analysis of multi-arm multi-stage clinical trials. First, we generalize the Dunnett (1955) test to derive efficacy and futility boundaries for a multi-arm multi-stage clinical trial. We show the boundaries control the f...
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Lancaster University
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664454 |