Structure-based design and synthesis of inhibitors of the mitotic kinases Nek2 and CDK2
Cyclin-dependent kinase 2 (CDK2) and Nek2 (Never-In-Mitosis A related kinases) are cell-cycle associated serine-threonine kinases that play an important role in the regulation of cellular proliferation and mitosis. Aberrant CDK2 and Nek2 activity are strongly associated with cancer, and inhibitors o...
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University of Newcastle upon Tyne
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664641 |